What is Paget's Disease of the Bone primarily characterized by?

Paget's Disease of the Bone is primarily characterized by increased metabolic activity and excessive bone remodeling. This condition involves a disruption in the normal process of bone turnover, leading to abnormal bone formation. In Paget's Disease, osteoclastic bone resorption is followed by a rapid and excessive formation of new bone by osteoblasts. The resulting new bone is often structurally disorganized and weaker than normal bone, which can lead to various complications, including pain, deformities, and an increased risk of fractures.

This heightened activity also causes affected bones to become enlarged and distorted, which can impact their mechanical properties and lead to symptoms like bone pain, pathological fractures, and, in some cases, arthritis due to changed joint biomechanics. The characteristic abnormalities seen in Paget's Disease can be observed through imaging studies, providing a clear indication of the condition's unique impact on the skeletal system.