What is the role of NSAIDs in musculoskeletal treatment?

Nonsteroidal anti-inflammatory drugs (NSAIDs) play a crucial role in the treatment of musculoskeletal conditions primarily by reducing pain and inflammation. They work by inhibiting the enzymes (cyclooxygenases, or COX-1 and COX-2) involved in the production of prostaglandins, which are compounds that promote inflammation, pain, and fever. By decreasing the levels of these inflammatory mediators, NSAIDs effectively alleviate symptoms associated with a variety of musculoskeletal issues, such as arthritis, strains, sprains, and other inflammatory conditions.

This pain relief allows individuals to improve their mobility and engage more comfortably in physical activities, which can be especially important in rehabilitation settings. The ability to manage pain and inflammation effectively can significantly enhance the overall treatment outcomes for musculoskeletal disorders.