Which cells are responsible for the resorption of bone?

Osteoclasts are the cells responsible for the resorption of bone. They play a critical role in the regulatory process of bone remodeling, which involves the breakdown of bone tissue to maintain the overall balance of bone formation and resorption. Osteoclasts are large, multinucleated cells derived from monocyte/macrophage lineage, and they work by secreting acids and enzymes that dissolve the mineral matrix and degrade collagen, leading to the liberation of calcium and phosphate into the bloodstream.

This process is crucial for maintaining bone health, enabling the replacement of old or damaged bone, and regulating mineral homeostasis in the body. Osteoblasts are involved in bone formation, while osteocytes, which are mature bone cells, help in the maintenance and communication within the bone matrix. Chondrocytes are cartilage cells and do not play a direct role in bone resorption; rather, they are involved in the development and maintenance of cartilage.