Which of the following describes osteoarthritis?

Osteoarthritis is characterized primarily as a degenerative joint disease that involves the gradual loss of articular cartilage. This deterioration leads to joint pain, stiffness, and a decrease in mobility, making it increasingly difficult for individuals to perform everyday activities. The process occurs as the cartilage—the smooth, protective tissue at the ends of bones—breaks down, often due to age, wear and tear, or injury. As the cartilage wears away, the underlying bones may begin to change, potentially leading to bone spurs and further joint damage. This condition is localized rather than systemic and does not involve an autoimmune response or infection, making it distinct from other forms of arthritis such as rheumatoid arthritis or septic arthritis. Thus, the emphasis on articular cartilage loss highlights the key mechanism behind osteoarthritis, confirming why this choice is the most accurate description of the condition.