Which of the following diseases can lead to abnormal bone curvatures and impaired motor function?

Paget's Disease of the Bone is known for its significant impact on bone remodeling, leading to abnormal bone structure and curvature. In this condition, there is an imbalance in the body's processes of bone formation and resorption, causing bones to become enlarged, softened, and weakened. This alteration in bone structure can lead to various complications, including deformities such as bowing of the legs or a curved spine, which can impair motor function by affecting posture and stability.

The disease often results in pain and increased susceptibility to fractures, further impacting mobility. As bones become deformed, the mechanical stress on joints may increase, possibly leading to additional complications in movement and function. Thus, Paget's Disease of the Bone is specifically associated with altered bone patterns and impaired mobility, making it the appropriate choice in this context.